FHL2蛋白的研究进展

来源 :军事医学科学院院刊 | 被引量 : 0次 | 上传用户：wx669

【摘要】

：

FHL蛋白是分子结构中仅含有4个半LIM结构域的蛋白质家族,人类FHL蛋白有4个成员:FHL1、FHL2、FHL3及ACT.它们通过LIM结构域与某些结构蛋白、激酶、转录调控因子等多种蛋白质相

【作者】

：

熊志红孙启鸿叶棋浓

【机构】

：

军事医学科学院生物工程研究所军事医学科学院放射与辐射医学研究所

【出处】

：

军事医学科学院院刊

【发表日期】

：

2004年期

【关键词】

：

FHL2 LIM 结构域功能相互作用蛋白肿瘤

【基金项目】

：

国家自然科学基金;国家重点基础研究发展计划(973计划)

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论文部分内容阅读

FHL蛋白是分子结构中仅含有4个半LIM结构域的蛋白质家族,人类FHL蛋白有4个成员:FHL1、FHL2、FHL3及ACT.它们通过LIM结构域与某些结构蛋白、激酶、转录调控因子等多种蛋白质相互作用,对某些基因的表达、细胞分化与发育、细胞骨架形成等发挥重要调控作用.FHL2是其中研究最深入的成员.本文介绍FHL2的结构特征、组织和细胞中的分布、FHL2与其他蛋白之间的相互作用、生物学功能,以及在肿瘤和其他疾病的发生和发展中的作用等方面的研究进展.

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FHL2蛋白的研究进展

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