Cefixime(CFIX)是一种结构不含N-甲硫四唑基(NMT)或N-甲噻二唑基(MTD)的头孢菌素。作者曾证实含NMTT或MTD的头孢菌素能以类似香豆素样药物的方式影响维生素K_1的代谢,从而引起凝血酶原减少症。维生素K_1-2,3-环化物是维生素K_1代谢循环中的中间产物,它在血浆中的蓄积是预示凝血酶原减少症的敏感标志。因此,作者采用测定维生素K_1-2,3-环氧化物的方 Cefixime (CFIX) is a cephalosporin structurally free of N-methylthiotetrazole (NMT) or N-methylthiadiazolyl (MTD). The authors have demonstrated that cephalosporins containing NMTT or MTD can affect the metabolism of vitamin K 1 in a coumarin-like manner that causes prothrombin reduction. Vitamin K_1-2,3-cyclization is an intermediate product of the vitamin K_1 metabolic cycle. Its accumulation in plasma is a sensitive marker of prothrombin reduction. Therefore, the author uses the determination of vitamin K_1-2, 3-epoxide side