论文部分内容阅读
目的比较促性腺素释放激素激动剂(gonadotropin releasing hormone anoloug,GnRH-a)超短方案和GnRH拮抗剂(GnRH antagonist,GnRH-ant)两种促排卵方案对体外受精-胚胎移植妊娠结局的影响,探讨促排卵方案的合理性。方法回顾性分析2011年1月-2012年12月在我院生殖中心进行IVF助孕的不孕患者,采用GnRH-a超短方案进行促排卵的196例,GnRH-ant方案261例,比较两种促排方案对妊娠结局的影响。结果 GnRH-a超短方案组和GnRH-ant组年龄分别为33.24±4.39、34.13±4.10岁,BMI分别为22.72±3.48、22.13±3.35,不孕年限分别为4.60±3.19、5.08±3.31年,HCG日内膜厚度分别为9.80±2.26、9.92±2.11cm,差异均无统计学差异(P>0.05)。GnRH-a超短方案组临床妊娠率为32.14%,GnRH-ant组为33.33%,两组间获卵数、成熟卵、受精卵数及临床妊娠率均未见统计学差异(P>0.05)。结论应用GnRH-a超短方案和GnRH-ant两种促排方案妊娠结局无统计学差异,GnRH-ant和GnRH-a超短方案可以作为卵巢储备功能不良的病人优选促排方案。
Objective To compare the effects of GnRH-a and GnRH antagonist (GnRH-ant) ovulation induction on pregnancy outcome of in vitro fertilization-embryo transfer (GFT) Discuss the rationality of ovulation induction program. Methods A retrospective analysis of 196 infertile patients with GnRH-a ultra-short protocol and ovulation-induced ovulation in our hospital from January 2011 to December 2012 was performed in IVF assisted pregnancy in our hospital, 261 cases of GnRH-ant were compared, Effect of different kinds of promoting blood pressure on pregnancy outcomes. Results The age of GnRH-a group and GnRH-ant group were 33.24 ± 4.39 and 34.13 ± 4.10 years old respectively, the BMI were 22.72 ± 3.48 and 22.13 ± 3.35 respectively, the duration of infertility was 4.60 ± 3.19 and 5. 08 ± 3.31 years, The intima-media thickness of HCG were 9.80 ± 2.26 and 9.92 ± 2.11 cm, respectively, with no significant difference (P> 0.05). The clinical pregnancy rate was 32.14% in GnRH-a group and 33.33% in GnRH-ant group. No significant difference was found in the numbers of oocytes, mature eggs, number of fertilized eggs and clinical pregnancy rate between the two groups (P> 0.05) . Conclusion There was no significant difference in pregnancy outcome between GnRH-a and GnRH-ant. Short-term GnRH-ant and GnRH-a regimens were the best choice for patients with ovarian reserve dysfunction.