环氧合酶又称前列腺素内过氧化物合成酶,是前列腺素合成的一种重要限速酶,花生四烯酸是其合成前列腺素E的前体。而各种前列腺素产物可参与维持机体的各种生理病理过程。哺乳动物的环氧合酶至少有2种形式:COX-1和COX-2。近年来大量研究表明COX-2的过度表达与肿瘤发生发展密切相 Cyclooxygenase, also known as prostaglandin endoperoxide synthase, is an important rate-limiting enzyme in the synthesis of prostaglandins, a precursor to prostaglandin E synthesis. A variety of prostaglandin products can participate in maintaining the body’s various physiological and pathological processes. There are at least 2 forms of cyclooxygenase in mammals: COX-1 and COX-2. In recent years, a large number of studies have shown that COX-2 overexpression and tumor development close phase