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目的:探讨生育年龄妇女癫痫并发内分泌紊乱的相关危险因素。方法:选取2010年6月~2014年3月在该院就诊的育龄期女性癫痫患者60例,调查患者基本情况、癫痫发作类型、病程、抗癫痫药物治疗等情况。结果:服用丙戊酸钠的患者多囊卵巢综合征(PCOS)发生率为32.26%,高于未服用组,差异有统计学意义(P<0.05);病程>5年患者PCOS发生率为32.14%,高于病程≤5年患者,差异有统计学意义(P<0.05);非条件logistic回归分析显示,服用丙戊酸钠是PCOS发生的危险因素。结论:生育年龄妇女癫痫并发内分泌紊乱的危险因素是服用丙戊酸钠,在临床治疗育龄妇女癫痫时应注意该药的合理使用。
Objective: To investigate the related risk factors of epilepsy complicated with endocrine disorders in women of childbearing age. Methods: From June 2010 to March 2014, 60 female patients of childbearing age were enrolled in this hospital. The basic condition, type of seizure, course of disease, antiepileptic drug treatment and so on were investigated. Results: The incidence of polycystic ovary syndrome (PCOS) in patients taking sodium valproate was 32.26%, which was significantly higher than that of the patients without taking sodium valproate (P <0.05). The incidence of PCOS was 32.14 %, Higher than that in patients with disease ≤ 5 years, the difference was statistically significant (P <0.05); unconditional logistic regression analysis showed that taking sodium valproate was the risk factor of PCOS. Conclusion: Risk factors for epilepsy complicated with endocrine disorders in women of childbearing age are taking sodium valproate, and should pay attention to the rational use of this medicine in the clinical treatment of women of childbearing age in epilepsy.