论文部分内容阅读
破伤风仍是新生儿死亡的主要原因之一。通常用破伤风抗毒素、镇静剂、抗生素及减少外来刺激等治疗方法,其效果令人失望。用大剂量镇静剂配合呼吸管理,使死亡率明显下降,但需要经高度的专业训练,不能普遍推广。已证明破伤风毒素阻止具有抑制性的递质r-氨基丁酸及甘氨酸的释放,破伤风的痉挛症状之发生与此有关。破伤风患者的突触后受体对r-氨基丁酸和甘氨酸的反应是正常的,故设想如能使神经末梢释放r-氨基丁酸和甘氨酸增加,则能增强抑制作用而减少痉挛。维生素B_6是一种辅酶,与谷氨酸脱羧酶共同作用,使谷氨酸转化成r-氨基丁酸。
Tetanus is still one of the major causes of neonatal death. Tetanus antitoxin, sedatives, antibiotics and other treatments to reduce external irritation are commonly used and the results are disappointing. With large doses of sedatives with respiratory management, the mortality rate decreased significantly, but requires a high degree of professional training, can not be generalized. Tetanus toxin has been shown to block the release of inhibitory transmitter r-aminobutyric acid and glycine, and the occurrence of tetanus spasms has been linked to this. Post-synaptic receptors in tetanus respond to r-aminobutyric acid and glycine as normal, so it is envisaged that if the release of r-aminobutyric acid and glycine are increased at the nerve endings, the suppressive effect may be enhanced and the spasm reduced. Vitamin B_6 is a coenzyme that, together with glutamate decarboxylase, converts glutamate into r-aminobutyric acid.