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分析三七总皂苷注射液致不良反应(ADR)的发生特点及相关因素,为临床合理使用三七总皂苷提供参考。对国内15年来发表的103例三七总皂苷致不良反应病例进行回顾性分析。在103例ADR报告中,>60岁的ADR发生率最高(41.7%);ADR最为常见的临床表现为药疹(50.5%);其次为过敏反应(20.4%)以及过敏性休克(9.7%)。ADR发生与诸多因素有关。严格用药指征,用药前详细询问过敏史,加强药物不良反应监测,促进临床合理用药。
To analyze the occurrence and related factors of ADR caused by Panax Notoginseng Saponins Injection and provide references for the rational use of Panax Notoginseng Saponins. In the past 15 years, 103 cases of Panax notoginseng caused adverse reactions were retrospectively analyzed. Among 103 cases of ADR, the highest incidence of ADR was> 60 years old (41.7%); the most common clinical manifestation of ADR was drug eruption (50.5%); followed by allergic reaction (20.4%) and anaphylactic shock (9.7%). ADR occurs with many factors. Strict indications for medication, before the drug asked in detail the history of allergies, strengthen adverse drug reactions monitoring, and promote clinical rational use of drugs.