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目的探讨鼻腔原发性恶性黑色素瘤的临床病理特征,并对其诊断和鉴别诊断进行讨论。方法收集12例鼻腔恶性黑色素瘤,观察其临床病理特点并进行免疫组化分析。结果 12例鼻腔恶性黑色素瘤中男5例,女7例。年龄38～75岁,平均56.5岁。病变主要发生于鼻腔,或鼻腔和鼻窦同时受累。肿瘤由上皮样、梭形及未分化小细胞等多种类型的细胞构成,通常血管周围细胞呈瘤样结构。免疫组化标记瘤组织HMB45、S-100和Vim均(+)。结论鼻腔恶性黑色素瘤临床较罕见,其与皮肤黑色素瘤相比具有不同的组织形态学特征,通常诊断较困难,但根据其组织学特征和免疫组化染色有助于与鼻腔其他原发肿瘤相鉴别。
Objective To investigate the clinicopathological features of nasal primary malignant melanoma and to discuss its diagnosis and differential diagnosis. Methods Twelve cases of nasal malignant melanoma were collected, and their clinicopathological features were observed and analyzed by immunohistochemistry. Results There were 5 males and 7 females in 12 cases of nasal malignant melanoma. Age 38 ~ 75 years old, average 56.5 years old. Lesions occur mainly in the nasal cavity, or both nasal and sinus involvement. Tumor from the epithelial like, spindle and undifferentiated small cells and other types of cells, usually perivascular cells were tumor-like structure. Immunohistochemistry labeled tumor tissue HMB45, S-100 and Vim are (+). Conclusions Nasal malignant melanoma is clinically rare. Compared with skin melanoma, nasal malignant melanoma has different histomorphological characteristics. It is usually difficult to diagnose nasal melanoma. However, histological features and immunohistochemical staining may be helpful for the diagnosis of nasal malignant melanoma. Identification.