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在染患伤寒的人群中,有一小部分(约2～4％)患者会转变为长期的带菌者。这对其他健康人构成了很大的危害,特别是这些患者作为血液制剂的提供者时。以往对伤寒带菌者多采用氨苄青霉素或复方新诺明,然长期使用已证实不够安全。喹诺酮类的环丙氟哌酸(ciprofloxacin)对肠杆菌(除厌氧肠菌外)也具有高度的效用。该药易于由肠道吸收,且毒性很低。有9例球寒带菌者按常规剂量试验观察了10个月,证实该药效果颇佳。9例中,有8例的伤寒杆菌已被清除,无一例产生任何
A small percentage (about 2-4%) of those infected with typhoid fever turn into long-term carriers. This poses a great risk to other healthy people, especially when these patients act as providers of blood products. In the past, ampicillin or cotrimoxazole was often used in typhoid carriers, but long-term use has not been proved safe enough. Quinolones, such as ciprofloxacin, are also highly effective against Enterobacteriaceae, in addition to anaerobic bacteria. The drug is easily absorbed by the intestine and is less toxic. 9 cases of cold-carrying carriers according to the conventional dose test observed for 10 months, confirmed that the drug effect is quite good. Of the 9 cases, 8 of the typhoid bacilli had been cleared, none of which produced any