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作者研究了表达分泌型麻疹血凝素 ( H)和补体成分 C3d融合物的 s H- 3C3d- DNA疫苗诱导中和抗体应答的情况。 用 p TR6 0 0表达载体构建两种疫苗质粒 :一种表达麻疹病毒 Edmonston株的分泌型血凝素 ( s H) ,另一种表达 C3d和 H的融合物 ( s H- 3C3d)。 s H包含 H的胞外部分
The authors studied the induction of neutralizing antibody responses by the sH-3C3d-DNA vaccine expressing the secreted measles hemagglutinin (H) and complement component C3d fusions. Two vaccine plasmids were constructed using the pTR6000 expression vector: a secreting hemagglutinin (sH) expressing the Edmonston strain of measles virus and another fusion (sH-3C3d) expressing C3d and H. s H contains the extracellular portion of H