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目的:建立以指纹图谱表达的中药多成分体系的药物动力学,亦谱动学的总量统计矩数学模型。方法:用总量统计矩原理阐明中药谱动学数学模型及参数关系。结果:建立了药物动力学与指纹图谱同时表征的二维变量的中药谱动学的数学模型与参数表征体系,包括总量零阶矩(VUCT)、总量响应率(VUCPWT)、总量一阶矩坐标(指纹图谱总量一阶矩,MCRTT;药物代谢总量一阶矩,MRTT)及总量二阶矩(指纹图谱二阶矩,VCRTT;药物代谢二阶矩,VRTT)。结论:所建立的中药谱动学的数学模型及参数体系能表征以指纹图谱表达的中药多成分的药物动力学行为,其计算方法比单个成分逐个测定计算更为方便,同时适用于未知成分药物动力学研究。
OBJECTIVE: To establish a pharmacokinetic and pharmacokinetic model of total multi-component maths expressed by fingerprinting. Methods: The principle of total amount of statistical moments to clarify the pharmacokinetic model of traditional Chinese medicine and parameter relationship. Results: The mathematical model and parametric characterization system of two-dimensional variables pharmacokinetic parameters including VUCT, total response rate (VUCPWT) and total volume of one Order moment (total first order moment of fingerprint, MCRTT; first order moment of drug metabolism, MRTT) and second order moment of total fingerprint (second order moment of fingerprint, VCRTT; second moment of drug metabolism, VRTT). Conclusion: The established mathematical model and parameter system of traditional Chinese medicine spectrum kinetics can characterize the multi-component pharmacokinetic behavior of traditional Chinese medicine expressed by fingerprints. The calculation method is more convenient than the single component calculation and calculation, and is suitable for the unknown component drugs Kinetic studies.