β型干扰素(Interferon-β,IFN-β)是主要由成纤维细胞产生的细胞因子,属于单一基因编码产生的蛋白质,可通过干扰病毒RNA或DNA复制而抑制病毒生长,并可显著增强NK细胞杀伤活性,通过促进MHCⅠ类分子表达而增强CTL对病毒感染细胞的识别和杀伤作用.临床上,IFN-β已用于多种疾病的治疗,对多发性硬化病(MS)治疗效果较好,为FDA批准的用于MS治疗唯一的生物制品类药物.另外,对多种病毒感染如HCV、HBV、HPV、HIV、HSV等都有不同的疗效.此外,IFN-β还有一定的抗肿瘤作用,对非小细胞型肺癌、乳腺癌、喉癌、结肠癌、肾癌等都有一定的疗效.本文从治疗MS、抗病毒以及抗肿瘤等多方面综述IFN-β临床应用的研究进展, Interferon-β (IFN-β) is a cytokine mainly produced by fibroblasts. It belongs to a protein encoded by a single gene and can inhibit virus growth by interfering with viral RNA or DNA replication and can significantly enhance NK Cytotoxicity and cytotoxicity of CTLs against virus-infected cells by promoting the expression of MHC class I molecules.Clinical studies have shown that IFN-β has been used in the treatment of various diseases and has a good effect on multiple sclerosis (MS) , Is the only biologic drug approved by the FDA for the treatment of MS In addition, there are different effects on a variety of viral infections such as HCV, HBV, HPV, HIV, HSV, etc. In addition, IFN- Tumor effect on non-small cell lung cancer, breast cancer, laryngeal cancer, colon cancer, kidney cancer, etc. This article reviews the clinical application of IFN-β in the treatment of MS, anti-virus and anti-tumor ,