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目的:探讨抗抑郁药氟西汀联合多潘立酮对功能性消化不良的治疗效果。方法:将97例功能性消化不良(functionaldyspepsia,FD)患者随机分成试验组47例和对照组50例,试验组给予氟西汀10mg/d,每晚睡前口服,多潘立酮10mg,3次/日;对照组单用多潘立酮10mg,3次/日,两组疗程均为8周,治疗期间均停用其它药物,分别于治疗前及治疗的第2、4、6、8周及随访时(第12周)进行疗效评价。结果:试验组治疗2周、8周和12周时的总有效率分别为36%、87%和84%,疗效明显高于对照组的18%、31%和31%,差异均有统计学意义,均为P<0.01。结论:氟西汀联合多潘立酮治疗功能性消化不良具有良好的治疗效果。
Objective: To investigate the therapeutic effect of antidepressant fluoxetine combined with domperidone on functional dyspepsia. Methods: Ninety - seven patients with functional dyspepsia (FD) were randomly divided into experimental group (n = 47) and control group (n = 50). The experimental group was given fluoxetine 10 mg daily, bed orally before bedtime, domperidone 10 mg, ; The control group with domperidone 10mg, 3 times / day, the two courses of treatment were 8 weeks, were discontinued during the treatment of other drugs, respectively, before treatment and treatment of 2,4,6,8 weeks and follow-up 12 weeks) for efficacy evaluation. Results: The total effective rate was 36%, 87% and 84% in the experimental group at 2 weeks, 8 weeks and 12 weeks respectively. The curative effect was significantly higher than that of the control group (18%, 31% and 31%, respectively) Significance, all P <0.01. Conclusion: Fluoxetine and domperidone have good therapeutic effect on functional dyspepsia.