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目的 :建立一种原位成瘤率高 ,早期局限生长于子宫的原位移植宫体肿瘤模型。方法 :41只新西兰大白兔 ,随机用悬液 (宫腔内 ,浆膜下 )注射法 ,瘤块 (宫腔 ,阴道 )置入法 ,内膜分离包埋法移植肿瘤 ,观察其原位成瘤率及宫外生长率。结果 :内膜分离包理法的原位成瘤率为 10 0 % ,明显高于经阴道瘤块置入法 ,宫腔内瘤块置入法及宫腔内悬液注射法 (P <0 .0 0 1) ,与浆膜下悬液注射法的原位成瘤率无差异 (P >0 .0 5 ) ,但无早期宫外生长 ;晚期宫外生长率与其它方法无明显差异 (P>0 .0 5 )。结论 :内膜分离包理法建立的模型原位成瘤率高 ,早期局限于子宫 ,晚期发生宫外转移生长 ,是一种较理想的原位移植VX2宫体肿瘤模型的方法
OBJECTIVE: To establish a orthotopic implantation of uterine tumor model with high rate of tumorigenesis in situ and early confinement in uterus. Methods: Forty-one New Zealand white rabbits were randomly divided into three groups: intrauterine injection, subendocardial injection, tumor implantation (intrauterine and vaginal) Tumor rate and extrauterine growth rate. Results: The in situ neoplasia rate of endometriosis was 100%, which was significantly higher than that of transvaginal neoplasm implantation, intrauterine tumor mass insertion and intrauterine injection (P <0. There was no difference in in situ tumorigenicity between subinjection of subserosal injections (P> 0.05), but no early ectopic growth (P> 0.05). The late extrauterine growth rate was not significantly different from other methods (P > 0 .0 5). CONCLUSION: The in situ neoplasia rate of the model established by the method of endometrial dissection is high, early confined to the uterus, late ectopic metastasis growth, is a more ideal method of orthotopic transplantation of VX2 uterine tumor model