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目的:分析探讨醋酸奥曲肽联合甲磺酸加贝酯治疗急性胰腺炎患者的效果及对血清炎症因子水平的影响。方法:选取我院2015年4月-2017年4月期间所收治的急性胰腺炎患者150例作为研究对象,将其随机分为A、B、C三组,各50例;A组患者施以醋酸奥曲肽治疗,B组患者施以甲磺酸加贝酯,C组患者施以醋酸奥曲肽联合甲磺酸加贝酯治疗,观察三组患者治疗效果,并检测治疗前后患者血清炎症因子水平。结果:治疗后,C组患者的治疗总有效率比A、B组患者均明显偏高,组间差异明显,P<0.05;且C组患者治疗后其血清炎症因子,包括CRP、TNF-α及IL-6的水平均比A、B组患者均明显偏低,P<0.05,具有统计学意义。结论:醋酸奥曲肽与甲磺酸加贝酯联合运用对于治疗急性胰腺炎的效果显著,能有效降低患者血清炎症因子水平,改善患者体征状况,促进患者康复,具有广阔的临床应用价值。
Objective: To investigate the effect of octreotide acetate plus gabexate mesylate in the treatment of patients with acute pancreatitis and its influence on the level of serum inflammatory cytokines. Methods: A total of 150 patients with acute pancreatitis admitted from April 2015 to April 2017 in our hospital were enrolled in this study. They were randomly divided into three groups (A, B and C), 50 cases each. Patients in group A Octreotide acetate treatment, patients in group B were treated with gabexate mesylate, and patients in group C were treated with octreotide acetate combined with gabexate mesylate. The therapeutic effect was observed in three groups and serum levels of inflammatory cytokines were measured before and after treatment. Results: After treatment, the total effective rate of treatment in group C was significantly higher than that in group A and B, with a significant difference between the two groups (P <0.05). The serum inflammatory factors, including CRP, TNF-α And IL-6 levels were significantly lower than the A, B patients were significantly lower, P <0.05, with statistical significance. Conclusion: Combined use of octreotide acetate and gabexate mesylate can significantly reduce the level of serum inflammatory cytokines in patients with acute pancreatitis, improve the patients’ signs and symptoms, and promote the recovery of patients with broad clinical value.