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目的观察金仁陈子方对母子分离复合应激诱导的肠易激综合征(IBS)大鼠的治疗作用,并探讨其作用机理。方法采用新生大鼠母子分离与避水应激复合法复制内脏高敏感性IBS大鼠模型,观察金仁陈子方对IBS大鼠内脏敏感性、避水应激排便粒数、血清一氧化氮(NO)含量、血清及结肠组织5-羟色胺(5-HT)含量的影响。结果与模型组比较,金仁陈子方高、低剂量组大鼠内脏敏感性显著降低(P<0.01),避水应激排便粒数显著减少(P<0.01),血清NO含量显著升高(P<0.01),血清及结肠组织5-HT含量均显著降低(P<0.05)。结论金仁陈子方可通过调节大鼠体内NO、5-HT水平,显著改善IBS模型大鼠肠道功能。
Objective To observe the therapeutic effect of Jinren Chenzifang on rats with irritable bowel syndrome (IBS) induced by maternal and child separated complex stress and to explore its mechanism. Methods The rat model of visceral hypersensitivity IBS was duplicated by maternal and neonatal isolation and water stress-induced stress. The effects of Jinren-Chenzigifang on the visceral sensitivity, the number of water-shock-induced defecation granules, the level of serum nitric oxide ) Content, serum and serotonin (5-HT) content in colon tissue. Results Compared with the model group, the visceral sensitivity was significantly decreased (P <0.01) and the number of water-resistant stress defecation granules was significantly decreased (P <0.01), serum NO content was significantly increased (P <0.01). The contents of 5-HT in serum and colon tissue were significantly decreased (P <0.05). Conclusion Jinren Chenzi Fang can significantly improve the intestinal function of rats with IBS by regulating the level of NO and 5-HT in rats.