本文报道由相应的原小檗碱季铵盐经NaBD_4还原方便地制得三个氘代四氢原小檗碱同类物。氘代位置及产物构型经质谱、核磁共振和红外光谱得到证实。类似地还制得具有较高比放射强度和放化纯度的氘标记四氢小檗碱和千金藤立定。 It is reported that three deuterated tetrahydroprotoberberine congeners are conveniently prepared from the corresponding original berberine quaternary ammonium salt by NaBD_4 reduction. The deuterated position and product configuration were confirmed by mass spectrometry, nuclear magnetic resonance, and infrared spectroscopy. Similarly, terbium-labeled tetrahydroberberine and pantothrin were produced with higher specific radioactivity and radiochemical purity.