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目的观察HIV合并结核感染者的免疫状况。方法利用结核感染T细胞检测法检测174例HIV感染患者和174例健康者的结核感染情况,并分析HIV合并结核感染患者的免疫状况。结果 HIV感染组结核阳性率为31.0%,对照组结核阳性率为1.7%,2组比较差异有统计学意义(χ2=54.57,P<0.01)。CD4/CD8比值≥0.71时HIV合并结核感染的阳性率为13.4%,CD4/CD8比值<0.71时HIV合并结核感染的阳性率为42.0%,2组比较差异有统计学意义(χ2=17.54,P<0.01)。CD4阳性T淋巴细胞计数≥200个/μl的有72例、CD4阳性T淋巴细胞计数为100个/μl~200个/μl的有45例、CD4阳性T淋巴细胞计数<100个/μl的有57例,3组结核感染率分别为6.9%、26.7%、65.0%,差异有统计学意义(χ2=52.24,P<0.01)。结论 HIV合并结核感染患者免疫功能降低,CD4 T淋巴细胞数目减少,且CD4 T淋巴细胞普遍<200个/μl。
Objective To observe the immune status of HIV-infected TB patients. Methods T-cell infection was used to detect tuberculosis infection in 174 HIV-infected patients and 174 healthy controls, and the immune status of HIV-infected TB patients was analyzed. Results The positive rate of tuberculosis in HIV-infected group was 31.0%, while the positive rate of tuberculosis in control group was 1.7%. There was significant difference between the two groups (χ2 = 54.57, P <0.01). The positive rate of HIV co-infection was 13.4% when the CD4 / CD8 ratio was 0.71 and 42.0% when the CD4 / CD8 ratio was <0.71. There was significant difference between the two groups (χ2 = 17.54, P <0.01). There were 72 cases with CD4 positive T lymphocyte count> 200 / μl, 45 cases with CD4-positive T lymphocyte count from 100 / μl to 200 / μl, CD4 + T lymphocyte count <100 / μl The infection rates of tuberculosis in 57 cases and 3 groups were 6.9%, 26.7% and 65.0%, respectively. The difference was statistically significant (χ2 = 52.24, P <0.01). Conclusion The immune function of HIV-infected patients with tuberculosis infection is decreased, the number of CD4 T lymphocytes is reduced, and CD4 T lymphocytes are generally <200 cells / μl.