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目的 :探讨血清心脏肌钙蛋白 I(c Tn I)在急性心肌梗死 (AMI)中的诊断价值。方法 :急性心肌梗死 (AMI)组患者 2 0例 ,不稳定型心绞痛 (U A)组 31例 ,陈旧性心肌梗死 (OMI)组 11例 ,危重病患者 87例 (非心血管疾病 )。AMI组患者系列采血测定血清 c Tn I和 CK- MB,U A与 OMI组、危重患者组均入院后次日晨取血 1次。结果 :c Tn I与CK- MB诊断 AMI的敏感性均为 10 0 % ,c Tn I诊断 AMI的特异性高于 CK- MB(P<0 .0 5 ) ;AMI时 c Tn I浓度高峰时间与 CK- MB平行 ,持续时间明显延长 (P<0 .0 1) ,溶栓患者高峰时间明显前移 (P<0 .0 1)。结论 :c Tn I诊断 AMI敏感性高 ,其特异性高于 CK- MB。且在血清中出现早且持续时间长。其峰值时间改变可用于判定 AMI的溶栓疗效
Objective: To investigate the diagnostic value of serum cardiac troponin I (cTn I) in acute myocardial infarction (AMI). Methods: 20 patients with acute myocardial infarction (AMI), 31 patients with unstable angina (UA), 11 patients with old myocardial infarction (OMI) and 87 patients with critically ill patients (noncardiovascular disease). Serum cTn I and CK-MB, UA and OMI were collected from patients in AMI group and those in critically ill patients were taken one morning after admission on the morning. Results: The sensitivity of cTn I and CK-MB in the diagnosis of AMI was 100%, the specificity of cTn I in diagnosing AMI was higher than that in CK-MB (P <0.05), while the peak time of cTn I in AMI In parallel with CK-MB, the duration was significantly prolonged (P <0.01). The peak time of thrombolysis patients was significantly advanced (P <0.01). Conclusion: The c Tn I diagnosis of AMI is highly sensitive and its specificity is higher than that of CK-MB. Appear early in the serum and last for a long time. The peak time change can be used to determine the thrombolytic efficacy of AMI