白鲜皮水提物能作用于2 ,4 ,6三硝基氯苯所致迟发型变态反应的效应相,有效地改善迟发型变态反应性肝损伤,在肝损伤12 h 分离的肝非实质细胞和肝细胞共培养体系中,白鲜皮水提物预处理肝非实质细胞明显地阻断了上清中谷丙转氨酶的释放,作用呈量效关系和时效关系,而预处理肝细胞则无影响。同样,白鲜皮水提物对Con A 引起的脾淋巴细胞增殖无抑制活性,诱导相给药对肝损伤亦无保护作用。以上结果提示白鲜皮水提物改善肝损伤的作用主要与选择性地抑制肝损伤时肝非实质细胞的功能有关 Aqueous extract of white fresh skin can act on the phase of late-type hypersensitivity induced by 2,4,6-trinitrochlorobenzene, effectively improving late-onset allergic liver injury, liver disassociation after liver injury 12 h In the co-culture system of parenchymal cells and hepatocytes, pretreatment of hepatic parenchymal cells with white water extracts significantly blocked the release of alanine aminotransferase from the supernatant. The effect was dose-effect relationship and time-dependent relationship, while pretreated hepatocytes were no effect. Similarly, the white water extract had no inhibitory activity on proliferation of splenic lymphocytes induced by Con A, and administration of the induced phase also had no protective effect on liver damage. The above results suggest that the effect of the aqueous extract of white fresh skin on liver injury is mainly related to the selective inhibition of the function of non-parenchymal liver cells during liver injury.