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胃癌的淋巴结转移是胃癌转移和术后复发的最主要转移方式之一,严重影响胃癌患者的预后。血管内皮生长因子(VEGF)可促进淋巴管的增生,其在胃癌组织中高度表达,研究显示VEGF与胃癌淋巴管的生成有关,阻止淋巴管的生成对肿瘤转移有重要的意义,抑制VEGF及肿瘤淋巴管形成将影响肿瘤组织的增生和扩散,利用VEGF抗体及受体拮抗剂可以阻断肿瘤转移。本文就VEGF与胃癌的淋巴管生成和淋巴结转移以及降低胃癌复发的研究做一综述。
Lymph node metastasis of gastric cancer is one of the most important metastasis of gastric cancer and postoperative recurrence, which seriously affects the prognosis of patients with gastric cancer. Vascular endothelial growth factor (VEGF) can promote the proliferation of lymphatic vessels, which is highly expressed in gastric cancer tissues. Studies have shown that VEGF is related to the lymphangiogenesis of gastric cancer, preventing the formation of lymphatic vessels is of important significance for tumor metastasis, inhibiting VEGF and tumor Lymphangiogenesis will affect the proliferation and proliferation of tumor tissue, the use of VEGF antibodies and receptor antagonists can block tumor metastasis. This article reviews VEGF and gastric cancer in lymphangiogenesis and lymph node metastasis and reduce the recurrence of gastric cancer.