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目的分析儿童过敏性紫癜肾炎(HSPN)的临床表现和实验室检查,探讨过敏性紫癜(HSP)肾损害的临床相关因素。方法研究对象为2004年1月至2007年8月中国医科大学附属一院儿科诊治的123例HSP患儿,将患儿分为尿检正常组即非肾炎组(55例)和尿检异常组即肾炎组(68例),分析其临床表现、实验室指标,进行统计学分析。结果皮疹持续时间、皮疹的反复、消化道症状、24h尿蛋白定量、尿5项微量蛋白、免疫球蛋白、补体C3、血小板两项指标[包括血小板计数(BPC),血小板平均体积(MPV)]两组比较差异均有统计学意义(P<0.01)。结论HSP肾损害的发生与皮疹持续时间、皮疹的反复、消化道症状有关,与关节症状无关。免疫球蛋白、补体C3、BPC、MPV的异常提示它们参与了HSPN的发病过程。
Objective To analyze the clinical manifestations and laboratory tests of Henoch-Schonlein purpura nephritis (HSPN) in children, and to explore the clinical factors related to renal damage in Henoch-Schonlein purpura (HSP). Methods From January 2004 to August 2007, 123 cases of children with HSP who underwent pediatric treatment in the First Affiliated Hospital of China Medical University were divided into two groups: normal non-nephritis (55 cases) and nephritis Group (68 cases), analyze their clinical manifestations, laboratory indicators, for statistical analysis. Results The duration of the rash, the recurrence of the rash, the symptoms of the digestive tract, the quantitation of 24-h urine protein, the five microalbuminuria, the immunoglobulin, the complement C3 and the platelet [including platelet count (BPC) and platelet mean volume The differences between the two groups were statistically significant (P <0.01). Conclusions The occurrence of HSP renal damage is related to the duration of rash, repeated rashes and gastrointestinal symptoms, but not to the symptoms of joints. Immunoglobulins, complement C3, BPC, MPV abnormalities suggest that they are involved in the pathogenesis of HSPN.