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目的 探讨 4 -去甲氧柔红霉素 (IDA)对小儿白血病的治疗效果和毒、副作用。方法 对使用IDA联合VLDex或Ara -C方案的小儿白血病患者 15例 ( 11例ALL ,4例ANLL)进行临床情况分析。结果 ALL的CCR率 77% ,平均CCR 17个月 ;而ANLL的CR率仅 2 / 4 ,且近期复发 1例。用IDA治疗ALL时 ,剂量为 2 0mg/m2 ,可获较高的CR和CCR率 ;而治疗ANLL时 ,2例 2 0mg/m2 者复发 1例 ,PR 1例 ,需 3 0mg/m2 才有助提高CR率。小儿使用IDA的主要毒、副作用是骨髓抑制、出血和感染 ,心脏、肝毒性较轻。结论 IDA联合化疗方案治疗小儿白血病的疗效较好
Objective To investigate the therapeutic effects and toxicities and side effects of 4 - deoxyribourimycin (IDA) on childhood leukemia. Methods Fifteen patients with ALL (11 ALL, 4 ANLL) with IDA combined with VLDex or Ara-C regimen were analyzed. Results The CCR rate of ALL was 77% with an average CCR of 17 months. However, the CR rate of ANLL was only 2/4 and 1 case of recent recurrence. IDA treatment of ALL, the dose of 20mg / m2, higher CR and CCR rate; and the treatment of ANLL, 2 cases of 20mg / m2 recurrence in 1 case, PR 1 cases, to be 30mg / m2 Help improve the CR rate. Pediatric use of IDA major poison, side effects are myelosuppression, bleeding and infection, heart, liver toxicity lighter. Conclusion The combination therapy of IDA and adjuvant chemotherapy is effective in the treatment of childhood leukemia