顺-二氯二氨铂(Ⅱ)〔顺铂, (1)〕为抗肿瘤药物,水溶液可发生水解,生成水合物(2),(3).曾有报道顺铂在等渗氯化钠注射液中室温贮藏24h约有3%生成(2)和(3);(2)、(3)可随之进一步分解生成无抗肿瘤活性且有剧毒的低聚物(4)与(5).本文用HPLC法测定(2)～(5),对(4)、(5)的测定限度为1mg/L.长期实验结果,(1)0.9%氯化钠溶液未检到(4)、(5),但在40℃时有(1)的分解发生.冷藏条件下,(1)的等渗氯化钠溶液贮藏一 Cis-dichloro-diammine platinum (II) [cisplatin, (1)] is an antitumor drug, the aqueous solution can be hydrolyzed to generate hydrates (2), (3). It has been reported cisplatin in isotonic sodium chloride (2) and (3); (2), (3) can be further decomposed to generate non-toxic and highly toxic oligomers (4) and (5 (2) to (5), the limits of determination of (4) and (5) were 1 mg / L. The long-term results were as follows: (1) 0.9% sodium chloride solution was not detected (4) , (5), but (1) decomposition occurred at 40 ° C. Under refrigerated conditions, the isotonic sodium chloride solution of (1)