以氨基硫脲为前体,经关环后与1,3-二溴丙烷合成了双1,3,4-噻二唑。再与不同的芳香醛及亚膦酸酯合成了一系列双噻二唑基-α-氨基膦酸酯。所得产品均采用IR、1HNMR、UV、31PNMR及元素分析表征;初步生物活性测试表明,该类化合物对黄瓜灰霉病毒、小麦赤霉病菌、苹果轮纹病毒和水稻纹枯病毒都具有明显的杀菌活性。 Thiosemicarbazide as a precursor, after ring closure and 1,3-dibromopropane synthesis of bis 1,3,4-thiadiazole. A series of bisthiadiazolyl-α-amino phosphonates were synthesized with different aromatic aldehydes and phosphonites. The obtained products were characterized by IR, 1HNMR, UV, 31PNMR and elemental analysis. The preliminary biological activity tests showed that these compounds have obvious effects on Botrytis cinerea, Gibberella zeae, Bactericidal activity.