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目的探讨血清上皮型钙黏蛋白(E-cad)在子宫内膜异位症血清中的表达及在诊断和预后评估中的作用。方法以酶联免疫法检测不同分期和术前术后的子宫内膜异位症患者、对照组血清中E-cad的含量,并分别进行比较。结果子宫内膜异位症组血清中E-cad含量较对照组明显升高(P<0.05);Ⅲ、Ⅳ期子宫内膜异位症患者血清中E-cad水平高于Ⅰ、Ⅱ期,但差异无统计学意义(P>0.05);术后1个月血清中E-cad水平低于术前(P<0.05)。结论E-cad在内异症发病中可能起一定的作用;其血清水平在子宫内膜异位症患者明显升高,虽与疾病严重程度无关,但与预后密切相关。
Objective To investigate the expression of serum E-cadherin in serum of patients with endometriosis and its role in the diagnosis and prognosis evaluation. Methods Enzyme linked immunosorbent assay was used to detect the levels of E-cad in serum of patients with endometriosis at different stages and preoperatively and postoperatively, and compared respectively. Results Serum levels of E-cad in endometriosis group were significantly higher than those in control group (P <0.05). Serum levels of E-cad in patients with stage Ⅲ and Ⅳ endometriosis were higher than those in stage Ⅰ and Ⅱ, But the difference was not statistically significant (P> 0.05). The level of E-cad in serum at one month after operation was lower than that before operation (P <0.05). Conclusions E-cad may play a role in the pathogenesis of endometriosis. The serum level of E-cadherin is significantly elevated in patients with endometriosis, which is not related to the severity of the disease but closely related to the prognosis.