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用放射免疫分析法检测 4 0例女性类风湿关节炎 (RheumatoidArthritis ,RA)患者血清中IL 1β和TNF α的水平 ,以 39名健康女性血清为对照。同时检测了RA病人血沉 (ESR)及C反应蛋白 (CRP)。结果 :女性RA患者血清中IL 1β和TNF α的水平高于对照组 ,且分别与ESR及CRP呈正相关 ;IL 1β与TNF α也呈正相关关系。提示 :IL 1β及TNF α是RA炎症及关节损伤重要介质 ,且能反映疾病活动状况 ,IL 1β和TNF α在致病中存在协同作用。
Serum levels of IL-1β and TNFα in 40 patients with rheumatoid arthritis (RA) were detected by radioimmunoassay. Serum levels of 39 healthy women were used as controls. ESR and C-reactive protein (CRP) were also measured in patients with RA. Results: Serum levels of IL-1β and TNF-α in female RA patients were significantly higher than those in control subjects, and were positively correlated with ESR and CRP. IL-1β was also positively correlated with TNF-α. It is suggested that IL 1β and TNFα are important mediators of RA inflammation and joint damage, and can reflect the disease activity. There is a synergistic effect between IL 1β and TNFα in pathogenesis.