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目的观察碳酸钙混悬液治疗儿童原发性胆汁反流性胃炎的疗效。方法2004-10—2006-10,对浙江大学医学院附属儿童医院经胃镜和24h动态胆红素监测仪(Bilitec 2000)确诊为原发性胆汁反流性胃炎的32例患儿,随机分成两组:A组15例,给予碳酸钙混悬液治疗4周;B组17例,给予碳酸钙混悬液加多潘立酮治疗4周,分别于治疗前及治疗2周、4周时观察患儿腹痛、腹胀、恶心、呕吐等症状积分变化,并于治疗4周后停药3d复查胃内24h胆汁反流情况。结果两组治疗4周后各症状积分较治疗前均有明显下降,差异有统计学意义(P<0.05);两组间治疗后各症状积分下降值比较,差异无统计学意义(P>0.05)。两组患儿治疗4周后24h胃内胆汁反流监测各指标与治疗前相比差异均无统计学意义(均为P>0.05)。结论碳酸钙混悬液对缓解儿童原发性胆汁反流性胃炎症状有明显疗效,但不能有效阻止胆汁反流,合用多潘立酮并无增效作用。
Objective To observe the curative effect of calcium carbonate suspension on children with primary bile reflux gastritis. Methods From October 2004 to June 2006, 32 children diagnosed as primary bile reflux gastritis by gastroscopy and 24 hours dynamic bilirubin monitor (Bilitec 2000) at Children’s Hospital Affiliated to Medical College of Zhejiang University were randomly divided into two groups Group A: 15 cases were treated with calcium carbonate suspension for 4 weeks; Group B, 17 cases were given calcium carbonate suspension plus domperidone for 4 weeks, respectively, before treatment and treatment of 2 weeks, 4 weeks observed in children with abdominal pain , Abdominal distension, nausea, vomiting and other symptoms change points, and in the treatment of 4 weeks after withdrawal 3d review of the stomach 24h bile reflux. Results After 4 weeks treatment, the score of each symptom in both groups decreased significantly compared with that before treatment (P <0.05). There was no significant difference in the scores of each symptom score between the two groups after treatment (P> 0.05 ). There was no significant difference between the two groups in the indicators of gastric intra-gastric bile reflux monitoring 24h after treatment for 4 weeks (all P> 0.05). CONCLUSION: Calcium carbonate suspension can relieve the symptoms of children with primary bile reflux gastritis, but it can not effectively prevent the reflux of bile. There is no synergistic effect of the combination of domperidone.