OBJECTIVE:The aims of this study were to determine the anti-inflammatory and analgesic effects of Yaotuitong(translation:low back and leg pain) capsules,a Chinese herbal preparation,and the histological changes it induces in experimental rats with chemically induced radicular neuritis.METHODS:Wistar rats were randomly divided into normal,model,Western medicine,and traditional Chinese medicine groups(n=24 per group).We surgically duplicated a chemical radicular neuritis model to simulate lumbar intervertebral disc protrusion.Granuloma formation was measured on postoperative days(PODs) 3,7,14,and 21.Prostaglandin E 2 and 5-hydroxytryptamine(inflammation mediators) levels in the surrounding tissue and the histology of the nerve root were determined on PODs 7 and 14.RESULTS:Yaotuitong capsules significantly reduced prostaglandin E 2(P<0.01) and 5-hydroxytryptamine(P<0.01)levels in tissue surrounding the nerve root.It also inhibited granuloma formation(P<0.05).CONCLUSION:Yaotuitong capsules have anti-in-flammatory and analgesic effects that can alleviate the discomfort of lumbar intervertebral disc protrusion. OBJECTIVE: The aims of this study were to determine the anti-inflammatory and analgesic effects of Yaotuitong (translation: low back and leg pain) capsules, a Chinese herbal preparation, and the histological changes it induces in experimental rats with chemically induced radicular neuritis. METHODS: Wistar rats were randomly divided into normal, model, Western medicine, and traditional Chinese medicine groups (n = 24 per group). We surgically duplicated a chemical radicular neuritis model to simulate lumbar intervertebral disc protrusion. Granuloma formation was measured on postoperative days (PODs) 3,7,14, and 21. Psortaglandin E2 and 5-hydroxytryptamine (inflammatory mediators) levels in the surrounding tissue and the histology of the nerve root were determined on PODs 7 and 14.RESULTS: Yaotuitong capsules significantly reduced prostaglandin E 2 (P <0.01) and 5-hydroxytryptamine (P <0.01) levels in tissue surrounding the nerve root. It also inhibited granuloma formation (P <0.05) .CONCLUSION: Yaotuitong capsules have anti-in-flammatory and analgesic effects that can alleviate the discomfort of lumbar intervertebral disc protrusion.