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目的:观察小儿豉翘清热颗粒联合注射用单磷酸阿糖腺苷治疗手足口病的临床疗效。方法:将146例普通型手足口病风热感冒夹滞证患儿随机分为2组,对照组72例采用注射用单磷酸阿糖腺苷治疗,观察组74例于对照组治疗基础上加用小儿豉翘清热颗粒治疗。统计2组患儿的临床症状消退时间及治愈时间,并统计2组的临床疗效及治疗期间不良反应发生情况。结果:治疗后,观察组发热消退时间、口腔溃疡消退时间、皮疹消失时间、咽痛消失时间、治愈时间均短于对照组,差异均有统计学意义(P<0.01)。观察组临床治疗总有效率为97.3%,明显高于对照组的66.7%,差异有统计学意义(P<0.01)。治疗期间,2组患儿均未见呕吐、腹泻等明显不良反应。结论:应用小儿豉翘清热颗粒联合注射用单磷酸阿糖腺苷治疗普通型手足口病风热感冒夹滞证患儿疗效显著且安全。
OBJECTIVE: To observe the clinical efficacy of Xiaoyao Qiaoqing Qingre granules in combination with inosine monophosphate for the treatment of HFMD. Methods: One hundred and sixty-six children with common cold and heat syndrome of hand, foot and mouth disease were randomly divided into two groups. The control group, 72 cases were treated with injection of adenosine monophosphate. The observation group was given 74 cases in the control group Qiao Alice with heat particles treatment. The clinical symptoms of two groups were statistically analyzed. The clinical symptoms and the cure time of the two groups were statistically analyzed. The clinical efficacy and incidence of adverse reactions in the two groups were also calculated. Results: After treatment, the fever subsided time, oral ulcer subsidence time, rash disappearance time, sore throat disappearance time and healing time were shorter in the observation group than in the control group (P <0.01). The total effective rate of clinical observation in observation group was 97.3%, which was significantly higher than that in control group (66.7%), the difference was statistically significant (P <0.01). During the treatment, no obvious adverse reactions such as vomiting and diarrhea occurred in both groups. Conclusion: The treatment of common cold-heat syndrome of hand-foot-mouth disease in children with Qi and heat-clearing granules combined with adenosine monophosphate is effective and safe.