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Klein EA,etal.JAMA,2011,306(14):1549-1556.关于硒和维生素E预防肿瘤的研究(SELECT)的最初研究没有发现补充硒或者维生素E能够减少前列腺癌的危险,却出现了与维生素E相关的前列腺癌发生的危险的增加,但是这种增加差异无统计学意义。长期的随访观察,以及更多的前列腺癌事件的发生进一步将会揭示维生素E与前列腺癌之间的关系。本文的目的就是明确在相对健康的人群中,长期使用维生素E和硒与发生前列腺癌危险之间的关系。
Klein EA, et al. JAMA, 2011, 306 (14): 1549-1556. Initial studies on the study of selenium and vitamin E in the prevention of tumors (SELECT) did not find supplementation with selenium or vitamin E to reduce the risk of prostate cancer, There was an increased risk of prostate cancer associated with vitamin E, but this increase was not statistically different. Long-term follow-up observation, and the occurrence of more prostate cancer events will further reveal the relationship between vitamin E and prostate cancer. The purpose of this article is to identify the relationship between the long-term use of vitamin E and selenium and the risk of developing prostate cancer in a relatively healthy population.