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口腔扁平苔藓(OLP)是一种常见的口腔黏膜炎症性疾病,易复发并存在恶变的可能,具体的病因和发病机制尚不清楚。细胞自噬是真核细胞生物中高度保守的生命现象,作为程序性细胞死亡的方式之一,在维持细胞内环境的稳态方面起到重要作用。目前关于细胞自噬与OLP发病及恶变的关系的相关报道较少,本文就细胞自噬与口腔扁平苔藓的联系作一探讨。
Oral lichen planus (OLP) is a common inflammatory disease of the oral mucosa that is prone to relapse and has the potential for malignant transformation. The exact etiology and pathogenesis of OLP are unknown. Autophagy is a highly conserved life-form in eukaryotic cells, and as one of the means of programmed cell death, it plays an important role in maintaining the homeostasis of the intracellular environment. Currently there are few reports on the relationship between autophagy and OLP pathogenesis and malignant transformation. In this paper, the relationship between autophagy and oral lichen planus is discussed.