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年龄相关性黄斑变性(age-related macular degeneration,AMD)是50岁以上人群中常见的一种不可逆的致盲性慢性眼病,其发生主要与遗传及环境因素有关,并涉及衰老、氧化应激、光毒性损害、局部炎症等多个方面。该文综述了AMD的危险因素及其相关机制。
Age-related macular degeneration (AMD) is a common and irreversible blinding chronic eye disease in people over 50 years of age. Its occurrence is mainly related to genetic and environmental factors and involves in aging, oxidative stress, Phototoxic damage, local inflammation and many other aspects. This article reviews the risk factors of AMD and its related mechanisms.