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柳氮磺胺吡啶为水杨酸与磺胺吡啶的偶氮化合物,具有抗菌、抗风湿和免疫抑制作用,用于溃疡性结肠炎及克隆氏病的治疗,也是治疗类风湿关节炎、强直性脊柱炎的常用药。近年来国内有文献报道其不良反应,现概述如下:1剥脱性皮炎刘杰等报道[1],患男,17岁,因强直性脊柱炎给予柳氮磺胺吡啶0.5,3/日,口服治疗,第4天加至2.0/日,用药后患者口周及耳际出现散在丘疹,痒,暗红色,全身皮肤散发暗红色丘疹,发痒,伴发热,
Sulfasalazine is an azo compound of salicylic acid and sulfapyridine with antibacterial, antirheumatic and immunosuppressive effects for the treatment of ulcerative colitis and Crohn’s disease as well as for the treatment of rheumatoid arthritis, ankylosing spondylitis Of commonly used drugs. In recent years, domestic literature reports its adverse reactions, are summarized as follows: 1 exfoliative dermatitis Liu Jie and other reports [1], suffering from male, 17 years old, given ankylosing spondylitis sulfasalazine 0.5,3 / day, oral treatment , The first 4 days to 2.0 / day, the patient’s mouth and ears after the onset of scattered papules, itchy, dark red, systemic skin exudes dark red papules, itching, with fever,