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同一证候的患者由不同病因引起者,或同一证候的模型由不同造型方法形成者,都可能会有不同的病理及疗效反应.过去的研究对此重视不足。本实验在大鼠脾虚型(醋酸性)胃溃疡模型上对两种不同的脾虚造型方法(Ⅰ、耗气破气加饥饱失常法;Ⅱ、利血平法)进行比较观察,并比较二者对同样药物(泰胃美)的治疗反应。结果两种模型在外观、体重、溃疡指数、粘连指数、病理组织学观察方面均未见明显差别,泰胃美对二者的疗效也基本一致。可能机制是两种模型的主要病理均是全身和局部的严重营养不良导致胃粘膜易损性增高、修复能力下降,从而显示同样的造模及治疗结果。本实验是研究“同证异理同治”的一个初步尝试。
Patients with the same syndrome may be caused by different etiologies, or those with the same syndrome may have different pathological and therapeutic responses. Past studies have paid insufficient attention to this. In this experiment, two different spleen-deficiency modeling methods (I, gas consumption, gas-breakage and hunger-satisfaction, II, and reserpine) were compared on a rat model of spleen deficiency (acetic acid) gastric ulcer, and comparisons were made. Therapeutic response to the same drug (Taiweimei). Results There was no significant difference in appearance, body weight, ulcer index, adhesion index, and histopathological observation between the two models. The therapeutic effect of Taiweimei on the two was basically the same. The possible mechanism is that the main pathology of both models is that systemic and local severe malnutrition leads to increased mucosal vulnerability and reduced ability to repair, thus showing the same model and treatment results. This experiment is a preliminary attempt to study “simultaneous evidence with the same treatment.”