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目的研究孕期低水平铅暴露对新生儿血清磷钙P、Ca、25(OH)D3及骨碱性磷酸酶(BALP)的影响。方法于新生儿娩出断脐后采集脐静脉血5ml分别检测血铅、血清磷钙、血清25(OH)D3及骨碱性磷酸酶,将新生儿以血铅值P50 64.32为界分为低铅组、高铅组,研究脐血铅对新生儿骨代谢相关指标的影响。结果新生儿脐血铅水平与其血清磷、钙和25(OH)D3负相关,与骨碱性磷酸酶水平呈正相关。高铅组与低铅组比较,血清25(OH)D3水平、血清钙几何均数水平显著降低;高铅组碱性磷酸酶水平显著高于低铅组。讨论孕期低水平铅暴露可能干扰了新生儿骨代谢。
Objective To study the effect of low level lead exposure during pregnancy on serum phosphorus, calcium, calcium (25) OH and bone alkaline phosphatase (BALP) in neonates. Methods Umbilical cord blood 5 ml were collected from neonates after the umbilical cord was delivered. Blood lead, serum calcium phosphate, serum 25 (OH) D3 and bone alkaline phosphatase were detected. The newborns were divided into low lead by the blood lead level P50 64.32 Group, high lead group, to study the effects of umbilical cord blood lead on newborn bone metabolism related indicators. Results The levels of cord blood lead in neonates were negatively correlated with serum phosphorus, calcium and 25 (OH) D3, but positively correlated with bone alkaline phosphatase. Compared with the low lead group, the level of serum 25 (OH) D3 and the level of serum calcium geometric mean decrease significantly in the high lead group and the low lead group; the alkaline phosphatase level in the high lead group was significantly higher than that in the low lead group. Discussion Low levels of lead exposure during pregnancy may interfere with neonatal bone metabolism.