【摘 要】
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Liver X receptors (LXRs) have anti-inflammatory properties.Whether LXRs play a role in posttranscriptional control of inflammatory cytokine expression is not cl
【机 构】
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Department of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang
论文部分内容阅读
Liver X receptors (LXRs) have anti-inflammatory properties.Whether LXRs play a role in posttranscriptional control of inflammatory cytokine expression is not clear.Here,we firstly identified that the synthetic LXR agonist T0901317 promoted IL-1β,IL-6 and TNFα mRNA degradation.Moreover,T0901317 destabilized TNFα mRNA through its 3’-untranslated region.In addition,T0901317 increased the expression of tristetraprolin (TTP),while antagonizing TTP with siRNA abrogated T0901317-mediated inflammatory cytokine mRNA decay.Interestingly,T0901317 repressed LPS-induced phosphorylation of ERK1/2 and p38 mitogen-activated protein kinase (MAPK) in THP-1 macrophages.The evidence presented here confirms that LXR activation with T0901317 inhibits the phosphorylation of ERK1/2 and p38 MAPK,likely resulting in the increased expression of TTP and the decay of LPS-induce inflammatory cytokine mRNAs.
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