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在筛选试验新药时,固应以疗效为前提,但一般药物多有一定毒性或副作用。为保证临床用药安全,应在评价疗效的同时必须把毒性考虑在内。关于新药的筛选和评定,已有专文讨论。本文着重对新药毒性观察的一般原则作初步的介绍和论述。新药临床前的实验资料是临床药理研究的基础,而动物毒理学研究是评价一种新药不可缺少的重要部分,研究的主要目的有下列几方面:(1)通过动物实验选出毒性小的药品,以避免对人体有害。(2)探知动物对药物的耐受剂量范围,借以估计人体可能耐受的剂量。在动物身上比较新药耐受剂量和有效剂
In the screening test of new drugs, solid response should be based on the premise, but most of the general drug has some toxicity or side effects. In order to ensure the safety of clinical medication, toxicity should be taken into account while evaluating the efficacy. About the screening and evaluation of new drugs, there have been discussions. This article focuses on the general principles of new drug toxicity observations for the introduction and discussion. The preclinical experimental data of new drugs are the basis of clinical pharmacology research. Animal toxicology research is an indispensable part of evaluating a new drug. The main purpose of the research is as follows: (1) Select the drugs with low toxicity through animal experiments , To avoid being harmful to the human body. (2) Detect the tolerated dose range of the animal to the drug, in order to estimate the dose that the human body may tolerate. Compare new drug tolerance doses and actives to animals