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目的:探讨青年脑梗死患者发病和复发与危险因素的相关性。方法:18-45岁脑梗死患者226例,采用NIHSS评估患者神经功能缺损程度,按病因进行TOAST分类。选取糖尿病、高血压、脂代谢异常、吸烟、饮酒、房颤、房扑、心肌梗死、心脏附壁血栓等危险因素为研究内容。采用Spearman等级相关分析评价NIHSS分级与TOAST分类之间的关系;采用logistic回归分析评价青年脑梗死复发与危险因素的相关性。结果:脑梗死复发14例,男11例(6.4%),女3例(5.6%)。NIHSS分级中轻度为主(75.2%)。而TOAST分类中,大动脉粥样硬化性脑卒中最多(47.8%),不明原因者19.5%。NIHSS分级与TOAST分类无关(P=0.96);糖尿病和高血压与青年脑梗死发病和复发相关(分别为P=0.042,OR=3.91,95%CI 1.12-14.24;P=0.047,OR=4.21,95%CI 1.12-14.24)。结论:在青年脑梗死发病和复发的危险因素中,糖尿病和高血压有显著相关性。
Objective: To explore the correlation between the incidence and recurrence of young cerebral infarction and risk factors. Methods: A total of 226 patients aged 18-45 years with cerebral infarction were enrolled in this study. NIHSS was used to evaluate the degree of neurological deficit. TOAST classification was performed according to the cause. The risk factors such as diabetes, hypertension, dyslipidemia, smoking, drinking, atrial fibrillation, atrial flutter, myocardial infarction, and mural thrombus were selected as the research contents. Spearman rank correlation analysis was used to evaluate the relationship between NIHSS classification and TOAST classification. Logistic regression analysis was used to evaluate the correlation between risk factors and relapse of young cerebral infarction. Results: The recurrent cerebral infarction in 14 cases, 11 males (6.4%) and 3 females (5.6%). NIHSS grading mildly dominated (75.2%). The TOAST classification, the largest atherosclerotic stroke (47.8%), 19.5% for unknown reasons. NIHSS grade was not associated with TOAST classification (P = 0.96); diabetes and hypertension were associated with the onset and recurrence of cerebral infarction in young adults (P = 0.042, OR = 3.91, 95% CI 1.12-14.24; 95% CI 1.12-14.24). Conclusion: Among the risk factors of the onset and recurrence of cerebral infarction in young people, there is a significant correlation between diabetes and hypertension.