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瑞典斯德哥尔摩Sabbatsberg医院从1964年开始在吸烟人群中小规模地以细胞学筛选的方法试图发现早期肺癌。1964～74年对1,700无症状的成人和少年吸烟者做了痰细胞学检查。被检者每日吸烟至少10支以上,不考虑性别和年龄。每人送痰标本3次,可疑病例则再重复3次。可疑或细胞学检查阳性病人送医院做临床检查。1975年后改为只对大量吸烟者进行检查,即45岁以上男性每天吸烟至少20根,至少达16年者。从1964～74年筛选的材料中发现6例早期支气管鳞状上皮癌。全部病例都经组织病理学证实,而有些病例细胞学阳性随访8～10年后始被证实。此外,有
In 1964, the Sabbatsberg Hospital in Stockholm, Sweden, tried to identify early-stage lung cancer in small and medium-sized populations by means of cytological screening. A sputum cytology was performed on 1,700 asymptomatic adult and juvenile smokers from 1964 to 74. Subjects smoked at least 10 cigarettes a day, regardless of gender and age. Samples were given 3 times per person, and suspicious cases were repeated 3 more times. Suspicious or cytologically positive patients were sent to the hospital for clinical examination. After 1975, only a large number of smokers were examined, that is, men over the age of 45 smoked at least 20 cigarettes per day for at least 16 years. Six cases of early bronchial squamous cell carcinoma were identified from materials screened from 1964 to 74 years. All cases were confirmed by histopathology, and in some cases cytology positive follow-up was confirmed after 8 to 10 years. In addition, there is