A Co3 O4 nanorod supported Pd electro-catalyst for the methanol electro-oxidation (MEO) has been fabricated by the combination of hydrother-mal synthesis and microwave-assisted polyol reduction processes. The crystallographic property and microstructure have been characterized using XRD, SEM and TEM. The results demonstrate that Pd nanoparticles (PdNPs) with a narrow particle size distribution (3?5 nm) are uni-formly deposited onto the surface of Co3O4 nanorods. Electrochemical measurements show that this catalyst having a larger electrochemically active surface area and a more negative onset-potential exhibits enhanced catalytic activity of 504 mA/mg Pd for MEO comparing with the Pd/C catalyst (448 mA/mg Pd). The dependency of logI against logv reveals that MEO on Pd-Co3O4 electrode is under a diffusion control. Electrochemical impedance spectroscopy (EIS) measurement agrees well with the CV results. The minimum charge transfer resistance of MEO on Pd-Co3 O4 is observed at?0.05 V, which coincides with the potential of MEO peak.