较新的应激定义为 :机体的不协调状态或内环境稳定受到威胁[1 ] ,其主要特征为机体受到内外环境刺激后发生交感肾上腺髓质及垂体 -肾上腺皮质活性增强。慢性应激一般指超过 2 4 h的持续或反复应激 ,该状态起因于持久的内激起 ,主要伴有神经、内分泌、免疫和行为等变化。许多疾 Newerer stresses are defined as the uncoordinated state of the body or the stability of the internal environment being threatened [1], the main feature of which is the increased activity of sympathetic adrenal medulla and pituitary-adrenal cortex after the body is stimulated by internal and external environment. Chronic stress generally refers to more than 24 h of sustained or repeated stress, which is due to a long lasting internal strife, mainly accompanied by neurological, endocrine, immune and behavioral changes. Many diseases