论文部分内容阅读
目的：比较3种不同给药方案在早孕药物流产中的临床效果。方法收集早孕患者375例的临床资料，将患者随机分为3组，A组患者单纯服用米非司酮+米索前列醇，B组患者服用米非司酮+米索前列醇+甲氨蝶呤，C组患者服用米非司酮+米索前列醇+达那唑。比较3组患者的临床效果。结果 A组患者完全流产109例（87.2%），不完全流产11例（8.8%），流产失败5例（4.0%）；B组患者完全流产123例（98.4%），不完全流产2例（1.6%），流产失败0例（0.0%）；C组患者完全流产121例（96.8%），不完全流产3例（2.4%），流产失败2例（1.6%）；B、C组患者完全流产率与A组比较，差异均有统计学意义（均P＜0.05）；B组患者的子宫出血量明显减少，阴道出血时间、孕囊排出时间明显短于C组患者，差异均有统计学意义（均P＜0.05）。结论甲氨蝶呤、达那唑辅助米非司酮配伍米索前列醇能明显提高药物流产的成功率，而甲氨蝶呤能较好地改善子宫出血症状，减不良反应的发生。“,”Objective To compare of three different dosing regimens in drug clinical effects of medical abortion in early pregnancy.Methods Clinical data of 375 cases of early pregnancy patients were randomly divided into three groups,A group of patients taking mifepristone+misoprostol alone,group B patients taking mifepristone+misoprostol+MTX,C patients taking mifepristone+misoprostol+danazol.Comparison of the clinical effects of the three groups of patients.Results A group of 109 cases of complete abortion patients(87.2%),incomplete abortion 11 cases(8.8%), abortion failed in 5 patients(4.0%);group B patients with complete abortion 123 cases(98.4%),two cases of incomplete abortion(1.6%),abortion failure 0 cases(0.0%);group C patients with complete abortion 121 cases(96.8%),incomplete abortion three cases(2.4%),two cases of abortion failure(1.6%);B,group C patients with complete abortion a group rate,the difference was statistical y significant(P<0.05);significantly reduce the amount of bleeding in patients in group B,vaginal bleeding,gestational sac discharge time was significantly shorter than that in group C patients,the differences were statistical y significant(P<0.05).Conclusion Methotrexate,danazol auxiliary mifepristone abortion drug can significantly improve the success rate,while methotrexate can better improve bleeding symptoms,reduce the incidence of adverse reactions.