维生素 C 自1933年开始人工合成以来,已广泛应用于临床。对其生理作用、临床应用的认识近年来又有显著进展。本文仅就近年来有关临床应用、实验研究的情况,结合我们临床实践的点滴体会作一简介。一、防治动脉粥样硬化和冠心病维生素 C 现已成为防治冠心病的一个重要措施,被人们所重视。在实验方面:发现使豚鼠食物中缺乏维生素 C,即可加速豚鼠的高胆固醇血症,促使该动物血管内膜脂质的迅速沉积。形态上与人的动脉粥样硬化相同,而且这种病变可经维生素 C 治疗后消失。给动物喂饲一种致动脉粥样硬化的饮食,且在饮食中有示踪 Vitamin C since 1933 began artificial synthesis, has been widely used in clinical. The understanding of its physiological role and clinical application has made remarkable progress in recent years. This article only in recent years on clinical applications, experimental studies, combined with our clinical experience bit by bit to make a brief introduction. First, prevention and treatment of atherosclerosis and coronary heart disease vitamin C has now become an important measure to prevent and treat coronary heart disease, which is valued by people. In the experiment: The discovery of the lack of vitamin C in guinea pig food can accelerate hypercholesterolemia in guinea pigs, prompting rapid deposition of the animal intima-lipid. Morphology and human atherosclerosis the same, but this disease can disappear after treatment with vitamin C. Animals were fed an atherogenic diet and traced in the diet