中药寻骨风醇提物对大鼠和小鼠具有显著的抗着床作用。从寻骨风中提得的马兜铃酸A对小鼠具有显著的抗着床和抗早孕活性,对大鼠则无。马兜铃酸A无雌性素和抗雌性素作用,而外源性的孕酮不能阻止它的抗早孕作用。此外羊膜囊注射此药可终止犬和大鼠的中期妊娠;同时检测血像、临床生化和主要脏器的形态学诸方面,均无明显异常。 Chinese medicine Xiongfeng alcohol extract has significant anti-implantation effect on rats and mice. Aristolochic acid A, which was extracted from hunt for wind, had significant anti-implantation and anti-early pregnancy activity in mice but not in rats. Aristolochic acid A has no estrogen and anti-estrogen effects, whereas exogenous progesterone does not prevent its anti-early-pregnancy effect. In addition, amniotic sac injection of this drug can stop the dogs and rats in the second trimester of pregnancy; simultaneous detection of blood, clinical biochemistry and the morphology of the main organs of various aspects, no significant abnormalities.