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目的:分析葛根素注射液致溶血反应发生的特点。方法:对1999-2003年国内文献报道的葛根素致溶血反应16例病例进行分析。结果:16例中男性12例,女性4例,≥60岁者10例(2例未报道年龄)。患者用药量200～600mg,1次/d。溶血反应多发生于首次用药3～10d,仅有3例(18.75%)是再次用药发生,既往有无药物过敏史均有可能发生溶血反应。临床以急性溶血性贫血为主要表现,如腰腿关节及全身疼痛,寒战发热,肉眼血尿或尿呈酱油色、浓茶色,实验室检查阳性指标有血RBC、Hb降低,尿中出现血红蛋白(尿潜血阳性)及红细胞。血免疫学检查可见葛根素特异性抗体。结论:葛根素注射液致溶血反应发生与多种因素有关,使用时应高度重视。
Objective: To analyze the characteristics of hemolysis caused by puerarin injection. Methods: 16 cases of puerarin hemolysis reported in domestic literature from 1999 to 2003 were analyzed. Results: Of the 16 patients, 12 were male, 4 were female, and 10 were ≥60 years (2 unreported ages). Patients with doses of 200 ~ 600mg, 1 / d. Hemolytic reaction occurred in the first medication 3 ~ 10d, only 3 cases (18.75%) is re-medication occurred in the past with or without drug allergy history may occur hemolytic reaction. The main clinical manifestations of acute hemolytic anemia, such as waist and leg joints and body pain, chills fever, gross hematuria or urine was soy sauce color, dark brown, laboratory tests positive indicators of blood RBC, Hb decreased, urine hemoglobin (urine Occult blood) and red blood cells. Blood immunology examination showed puerarin-specific antibodies. Conclusion: The hemolysis reaction induced by puerarin injection is related to many factors, and should be given high priority when used.