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低氧诱导因子对调节骨与关节软骨发育、形成、再生及维持细胞外基质代谢平衡起着重要作用。骨关节炎是由多种原因引起的关节软骨退化损伤、关节边缘和软骨下骨反应性增生。骨关节炎发病机制仍不清楚，探讨低氧诱导因子与骨关节炎的关联，可为有效防治骨关节炎提供更多的理论依据。“,”Hypoxia-inducible factors (HIFs) play an important role in development, formation, regeneration and metabolism of extracellular matrix among bone and cartilage. Osteoarthritis (OA) is caused by many reasons, which result in degeneration and damage of joint cartilage and reaction regeneration of joint margin and subchondrobone. The etiology of OA remains uncertain; the relationship between HIFs and OA could provide scientific data for OA prevention and control.