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本文对肺结核慢性传染源病人排出的结核菌,连续进行3次药物敏感试验发现,多数病史较短、病情较单纯的不住院治疗的慢性传染源病人,仍对多种抗结核药物敏感,只要重新确定治疗方案坚持治疗,其中大多数仍会获得治愈,达到痰菌阴转的目的;病史长、病情复杂、长期排菌的住院治疗的难治病人中大多已经对多种药物产生耐药性,可以估计到再继续化疗的愈后不佳。对新分离的菌株进行豚鼠的毒力试验表明,化疗时间长、对多种药物已产生耐药性的结核菌,其毒力变为弱型的机会显著增加。化疗时间在10年以上,对多种药物同时耐药的结核菌中仍有强毒力型存在。
In this paper, TB patients discharged from patients with chronic infectious pulmonary tuberculosis were tested for drug susceptibility three consecutive times and found that the majority of patients with chronic infectious diseases whose disease history is relatively simple and not hospitalized were still sensitive to various anti-tuberculosis drugs. Determine treatment adherence to treatment, most of whom will still be cured, to achieve the purpose of sputum negative conversion; long history, the condition is complicated, long-term discharge of bacteria refractory patients hospitalized mostly have resistance to a variety of drugs , It can be estimated to continue the poor prognosis of chemotherapy. Virulence tests on newly isolated strains of guinea pigs have shown a significant increase in the virulence of TB strains that have become refractory to various drugs for a long time in chemotherapy. Chemotherapy time in more than 10 years, while a variety of drug-resistant strains of Mycobacterium tuberculosis there is still a virulent type exists.