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目的:观察子痫前期与妊娠期高血压患者血清T h1型(IL-2、TNF-α)和T h2型细胞因子(IL-10)水平,以及T h1/T h2比值(IL-2/IL-10、TNF-α/IL-10)的变化,探讨这些变化在子痫前期和妊娠期高血压发病中的作用与意义。方法:采用放射免疫分析法(R IA)测定22例子痫前期、15例妊娠期高血压和32例正常孕妇(对照组)血清IL-2、IL-10和TNF-α浓度,并计算T h1/T h2比值;比较3组间细胞因子水平及T h1/T h2比值的差异。结果:3组间,血清IL-2、IL-10和TNF-α浓度差异均无显著性(P均>0.05)。子痫前期组血清IL-2/IL-10比值显著高于对照组(P<0.05),血清TNF-α/IL-10比值显著高于妊娠期高血压组、对照组(P均<0.025)。结论:子痫前期患者血清T h1/T h2比值显著增高。血清细胞因子平衡改变是子痫前期的重要病理生理变化,可能与子痫前期的发生、发展有关。
OBJECTIVE: To observe the changes of serum T-type 1 (IL-2, TNF-α) and T-type 2 cytokines (IL-10) and the ratio of T h1 / T h2 in serum of patients with preeclampsia and gestational hypertension IL-10, TNF-α / IL-10), to explore the role and significance of these changes in the pathogenesis of preeclampsia and gestational hypertension. Methods: Serum levels of IL-2, IL-10 and TNF-α in 22 cases of preeclampsia, 15 cases of gestational hypertension and 32 normal pregnant women (control group) were determined by radioimmunoassay (RIA) / T h2 ratio; cytokines levels and T h1 / T h2 ratio between the three groups were compared. Results: There were no significant differences in the concentrations of IL-2, IL-10 and TNF-α between the three groups (all P> 0.05). The ratio of serum IL-2 / IL-10 in preeclampsia group was significantly higher than that in control group (P <0.05), the serum TNF-α / IL-10 ratio was significantly higher than that in gestational hypertension group and control group . Conclusion: The serum T h1 / T h2 ratio in patients with preeclampsia was significantly higher. Serum cytokine balance changes is an important pathophysiological changes in preeclampsia, may be related to the occurrence and development of preeclampsia.