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目的:观察纳络酮治疗重型流行性乙型脑炎的疗效。方法:选择住院患儿随机分成两组,治疗组52例,对照组50例。治疗组在综合治疗基础上加用纳络酮0.02mg/kg静推,每8小时一次。结果:治疗组治愈42例,有效8例,无效2例,有效率96.15％(50/52);对照组治愈28例,有效7例,无效15例,有效率70％(35/50)。两组治愈率相比有显著差异(P<0.05),且治疗组在退热、止惊、催醒方面较对照组时间明显缩短(P<0.05)。结论:尽早使用纳络酮对控制重型乙型脑炎极期症状,缩短病程,提高治愈率,降低病残率和病死率有显著作用。
Objective: To observe the efficacy of naloxone in the treatment of severe Japanese encephalitis. Methods: The hospitalized children were randomly divided into two groups: treatment group (52 cases) and control group (50 cases). Treatment group on the basis of comprehensive treatment plus naloxone 0.02mg / kg push every 8 hours. Results: In the treatment group, 42 cases were cured, 8 cases were effective and 2 cases were ineffective. The effective rate was 96.15% (50/52). The control group was cured in 28 cases, effective in 7 cases and ineffective in 15 cases. The effective rate was 70% (35/50). There was significant difference between the two groups in cure rate (P <0.05), and the treatment group was significantly shorter than the control group in antipyretic, anticonvulsant and awakening (P <0.05). Conclusion: As soon as possible, naloxone has a significant effect on controlling the extreme symptoms, shortening the course of disease, improving the cure rate, reducing the morbidity and mortality of severe B encephalitis.